Fri Sep 02 2022

22 articles - From Friday Aug 26 2022 to Friday Sep 02 2022

parm_toc.knit

Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Kidney Int

Barriers to Accessing Essential Medicines for Kidney Disease in Low and Low Middle Income Countries|.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Kidney Dis

Sex Disparity in Cause-Specific and All-Cause Mortality Among Incident Dialysis Patients.

Compared with male patients, female patients had a higher risk of all-cause mortality in the first 5 years post-dialysis initiation, a difference driven by higher mortality from infections and dialysis withdrawals. These findings may inform the study of sex differences in mortality in other geographic settings.

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Clin J Am Soc Nephrol

Arterial Stiffness and Chronic Kidney Disease Progression in Children.

Pulse wave velocity is increased in children with CKD but does not associate with eGFR or CKD progression.

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Prolonged Intermittent Kidney Replacement Therapy.

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The Relationship between Rate and Volume of Intravenous Fluid Administration and Kidney Outcomes after Angiography.

We tested for the interaction between fluid volume and duration of fluid administration, categorized as 6 hours. Mean fluid volumes <964 ml may be associated with a higher risk for the primary outcome, although residual confounding cannot be excluded.

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J Am Soc Nephrol

Blood Transcriptomes of SARS-CoV-2-Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity.

The blood transcriptome of KTRs affected by COVID-19 shows decreases in T cell and adaptive immune activation pathways during acute disease that, despite reduced immunosuppressant use, associate with severity. These pathways show recovery after acute illness.

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Carbamylation of Integrin a IIb ß 3: The Mechanistic Link to Platelet Dysfunction in ESKD.

Chronic urea overload significantly increases cyanate concentrations in patients with ESKD, leading to carbamylation, an irreversible modification of proteins and peptides. Methods To investigate carbamylation as a potential mechanistic link between uremia and platelet dysfunction in ESKD, we used liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) to quantify total homocitrulline, and biotin-conjugated phenylglyoxal labeling and Western blot to detect carbamylated integrin activity suggests amino acid administration during dialysis may help to normalize platelet function.

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Expansion of Escherichia-Shigella in Gut Is Associated with the Onset and Response to Immunosuppressive Therapy of IgA Nephropathy.

Fecal microbiota samples were collected from al participants and analyzed using 16S ribosomal RNA sequencing. Results Decreased in IgAN pathogenesis.

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Hypoxia-Inducible Factor - Prolyl Hydroxyl Domain Inhibitors: From Theoretical Superiority to Clinical Non-inferiority Compared to Current ESAs?

Other safety signals came from secondary analyses of some of the other randomized clinical trials, including a higher incidence of thrombosis. A more extensive clinical experience with post-marketing data on hard safety issues is needed to define better when and how to use HIF-PHD inhibitors compared to already available ESA.

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Kidney Int

Hemopexin Accumulates in Kidneys and Worsens Acute Kidney Injury by Causing Hemoglobin Deposition and Exacerbation of Iron Toxicity in Proximal Tubules.

Furthermore, the protective effect of deferoxamine in cisplatin-induced AKI was apparent in hemopexin wild type, but not in hemopexin knockout mice, further implicating hemopexin as a mediator of iron toxicity in AKI. Thus, our findings demonstrate that hemopexin accumulates in the kidneys and worsens kidney injury in AKI by increasing hemoglobin deposition on proximal tubular cells to exaggerate hemoglobin-induced cell injury.

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PHYOX2: A Pivotal Randomized Study of Nedosiran in Primary Hyperoxaluria Type 1 or 2.

In the nedosiran arm, the incidence of injection-site reactions was 9% (all mild and self-limiting). In conclusion, participants with PH1 receiving nedosiran had clinically meaningful reductions in Uox, the mediator of kidney damage in PH.

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Nephrol Dial Transplant

Association between kinetic of Anti-Neutrophil Cytoplasmic Antibody (ANCA), renal survival and relapse risk in ANCA-glomerulonephritis.

ANCA kinetic after ANCA-GN diagnosis is associated with outcomes. MPO-ANCA recurrence/persistence identifies patients with a lower potential of renal recovery and a higher risk of kidney failure, while PR3-ANCA recurrence/persistence identifies patients with a greater relapse risk. Thus, ANCA kinetic may help identify patients with a smoldering disease.

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Association of single and serial measures of serum phosphorus with adverse outcomes in patients on peritoneal dialysis: results from the international PDOPPS.

This highlights the need for improved treatment strategies in this population. Serial SPhos measurements should be considered when assessing patients' risks of adverse outcomes.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Nephrol Dial Transplant

Transition of care of adolescent kidney transplant recipients - A call to action.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Clin J Am Soc Nephrol

Processes of Care in Survivors of Acute Kidney Injury followed in Specialized Post-Discharge Clinics.

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Kidney Int

Thin basement membrane lesion is not only a collagen IV nephropathy: Don't underestimate "decorative" additions to collagens.

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Nat Rev Nephrol

Cellular recovery after prolonged warm ischaemia.

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In vivo slit diaphragm dynamics in Drosophila.

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Leveraging lysine metabolism for renoprotection.

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NCKs are essential to podocyte-GBM interactions.

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YAP and TAZ regulate stromal cell development.

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Letters&Replies

Letters to the editors and authors’ replies

J Am Soc Nephrol

Financial Barriers to the Optimal Use of Peritoneal Dialysis in France and Europe, as in the United States.

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